THE INFLUENCE OF STIRRING RATE IN EMULSION SOLVENT EVAPORATION METHOD ON BIOPHARMACEUTICAL PROPERTIES OF MICROPARTICLES CONTAINING ACETAMINOPHEN
DOI:
https://doi.org/10.20903/masa/nmbsci.2021.42.6Keywords:
stirring rate, acetaminophen, microparticles, emulsion solvent evaporation technique, biopharmaceutical propertiesAbstract
Acetaminophen is widely used for musculoskeletal pain management, generally for arthritis, in elderly people and for reduction of fever in colds, flu and infections. Using the acetone/liquid paraffin solvent system, cellulose-based-microparticles were prepared by the emulsion solvent evaporation technique. The aim of this work was to evaluate the influence of stirring rate on: encapsulation efficiency, in-vitro drug release, release kinetics and morphology of microparticles. The drug loading ranged from 13% to 15%, while the encapsulation efficiency ranged from 67% to 77%. А directly proportional dependence among stirring speed and encapsulation efficiency is observed. Drug release follows Higuchi model and the release mechanism is dominantly a Fickian diffusion. For one trial, a non-Fickian diffusion has been observed. As it can be seen from the microphotographs, both spherical and angular microparticles are obtained.
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